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ONTOLOGY REPORT - ANNOTATIONS

Term:choline transmembrane transporter activity
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Accession:GO:0015220 term browser browse the term
Definition:Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
Synonyms:exact_synonym: choline permease activity
 narrow_synonym: amino acid/choline transmembrane transporter activity
 alt_id: GO:0005306
 xref: Reactome:R-HSA-5658483 "Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol";   reactome:R-HSA-429594 "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol";   reactome:R-HSA-444433 "Cho transports from the extracellular space to the cytosol";   reactome:R-HSA-6797956 "SLC44A1 transports Cho from cytosol to mitochondrial matrix"

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choline transmembrane transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 enables ISO (PMID:9687576) ARUK-UCL
RGD		 PMID:9687576 PMID:11553644 RGD:628453 NCBI chrNW_004624855:2,623,595...2,661,739
Ensembl chrNW_004624855:2,623,547...2,659,742 		JBrowse link
G Slc44a1 solute carrier family 44 member 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624758:5,963,281...6,152,870
Ensembl chrNW_004624758:5,960,094...6,151,653 		JBrowse link
G Slc44a2 solute carrier family 44 member 2 (CTL2 blood group) enables
NOT|enables		 ISO (PMID:20410607), (PMID:23651124), (PMID:33789160)
(PMID:10677542), (PMID:20665236)		 UniProt PMID:10677542 PMID:20410607 PMID:20665236 PMID:23651124 PMID:33789160 NCBI chrNW_004624828:2,655,107...2,678,347
Ensembl chrNW_004624828:2,655,113...2,677,135 		JBrowse link
G Slc44a4 solute carrier family 44 member 4 enables ISO (PMID:28013291)
(PMID:23651124)		 UniProt PMID:23651124 PMID:28013291 NCBI chrNW_004624754:24,368,697...24,381,959
Ensembl chrNW_004624754:24,368,716...24,382,397 		JBrowse link
G Slc44a5 solute carrier family 44 member 5 enables ISO (PMID:23651124) UniProt PMID:23651124 NCBI chrNW_004624742:21,258,331...21,610,174
Ensembl chrNW_004624742:21,555,828...21,610,197 		JBrowse link
G Slc5a7 solute carrier family 5 member 7 enables IEA Ensembl
UniProt		 GO_REF:0000107 GO_REF:0000117 NCBI chrNW_004624749:11,347,602...11,371,113
Ensembl chrNW_004624749:11,347,609...11,371,330 		JBrowse link
G Slc6a8 solute carrier family 6 member 8 ISO RGD PMID:1633856 RGD:737698 NCBI chrNW_004624946:389,806...396,653 JBrowse link
choline:sodium symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc5a7 solute carrier family 5 member 7 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624749:11,347,602...11,371,113
Ensembl chrNW_004624749:11,347,609...11,371,330 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 16258
    transporter activity 1091
      transmembrane transporter activity 1004
        organic cation transmembrane transporter activity 73
          choline transmembrane transporter activity 7
            ABC-type choline transporter activity 0
            choline:sodium symporter activity 1
paths to the root